Made in India medicine cures heart damage: A study on fruits, flies, and rats has found that a drug developed by India’s Defense Research and Development Organization (DRDO) can cure heart damage caused by a protein of the coronavirus. can do. Researchers from the University of Maryland have identified how a specific protein of SARS-Cov-2, the coronavirus, damages heart tissue.
They then used a drug called 2DG to reverse the toxic effect of that protein on the heart Big advantage of Made in India medicine Made by Dr. Reddy’s Laboratories in collaboration with DRDO, this drug 2DG is an oral drug. The coronavirus depends on glycolysis or the breakdown of glucose for energy. The drug interferes with the process of glycolysis and stops the growth of the virus.
The study says that people with Kovid-19 have a significant risk of swelling of the heart muscle, abnormal heartbeat, blood clots, stroke, heart attack, and heart failure for at least one year after infection. There is more risk. Scientists claim Scientists at the University of Maryland, Baltimore, US, used a drug to reverse the toxic effects of the SARS-Cov-2 virus protein on the heart. Jay Han, the senior author of the corresponding study report, said, ‘Our research shows that SARS-CoV-2 proteins can cause major damage to specific tissues in the body- As is the case with other viruses like HIV and Zika.
The claim in the report of Nature Communications Biology The report of the study on heart cells of fruit, flies, and rats is published in Nature Communications Biology. Although scientists around the world rapidly develop vaccines and drugs to reduce the severity of the COVID-19 disease, the study says these treatments do not protect the heart or other organs from the damage that a mild infection would cause. Might as well. Last year, Han and his team identified the most toxic proteins of the coronavirus in a study using fruit flies and human cells.
According to the study, they found that the drug ‘Selinexor’ reduced the toxicity of one of these proteins, but not of the other, known as NSP6. ‘Most poisonous coronavirus proteins turned out’ In their new research, they found that NSP6 turned out to be the most toxic coronavirus protein in the fruit fly’s heart. According to this study, the researchers found that the NSP6 protein controlled the fruit fly’s cells in its heart to trigger the glycolysis process, which enables the cells to burn the sugar glucose for energy.
Normally, heart cells use fatty acids as an energy source, but during heart failure, the sugar is metabolized as these cells attempt to repair the damaged tissue. The team involved in the research also found that the NSP6 protein caused damage by disrupting the mitochondria, the “powerhouses” of cells that produce energy from sugar metabolism. The team then blocked sugar metabolism in the heart cells of fruit flies and mice using the drug 2-deoxy-D-glucose (2DG). The study said that the drug reduced damage to the heart and mitochondria caused by the NSP6 protein.